Comparative Accuracy of 6 U.S. Allergy Panels

Key Findings

• PAX correctly identified 100% of samples (12/12)
• All extract-based tests showed inconsistent performance
• Several assays demonstrated high false-positive or false-negative rates
• Reproducibility varied substantially between laboratories

Performance Overview

*Except negative controls

Core Conclusion

Component-based molecular testing demonstrated superior diagnostic
accuracy and reproducibility compared to extract-based IgE assays.

Extract-based panels showed:

• Low detection of relevant molecular allergens

• High false-positive and false-negative rates

• Inconsistent reproducibility

Clinical Implication

Test selection directly influences:

• llergen selection for immunotherapy

• Diagnostic confidence

• Treatment decisions

Choosing a highly accurate and reproducible assay is essential for reliable
allergy management.

References

Olivry T, Mas-Fontao A, Spencer M. "Comparative accuracy of 6 common allergy panels." dvm360, March 31, 2026.