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Next+ Serum Test

Next+ Serum Test is an innovative serological test for detecting IgE in the serum of dogs and cats.

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Next+ Serum Test is an innovative serological test for detecting IgE in the serum of dogs and cats. It has all the benefits of our proprietary oligoclonal technology, and it employs the new generation of CCD blockers – Next+ has the highest specificity and sensitivity in the market.

Key Facts about Next+ Technology

  • Ground-breaking technology
  • Uses new-generation semisynthetic CCD blockers – Read more about CCDs
  • Contains three unique monoclonal antibodies from recombinant IgE (recognising three specific IgE epitopes)
  • 100% specificity for IgE with high sensitivity
  • No cross-reaction with other immunoglobulins (such as IgG)
  • Only gives relevant positive results
  • High treatment compliance
  • Specially developed for dogs and cats
  • Short-term medications do not have to be discontinued
  • Examines the most relevant indoor and outdoor allergens
  • Available for screening or as a complete panel
  • Results clearly set out and easy to interpret

Clear advice and support provided by our allergy experts

Next+ Screening Environmental

This environmental screening indicates whether any of the tested allergens are positive (positive result), or whether they are all are negative (negative result). It does not indicate specific allergens (except for individual Flea result).

Next+ Complete Environmental

This provides individual results for the tested allergens. An allergen-specific immunotherapy can then be ordered according to the results. The results come with clear treatment advice.

CCDs

What are CCDs and where are they found?
CCDs are cross-reactive carbohydrate determinants, which are the carbohydrate chains found in glycoproteins. They are part of the structure of many allergy-causing proteins, especially plant-based allergens like pollen.

How are CCDs involved in allergy?
During an allergic reaction, IgE is produced against the carbohydrate chains as well as the allergen’s proteins. Studies have confirmed that this occurs in 30% of humans, dogs and cats. The IgE against CCD chains does not seem to be clinically relevant.

Why is it important to block CCDs?
Blocking CCDs means that the specificity of the in vitro test is enhanced. Evidence shows that the correlation with intradermal testing is also improved.

FAQ

1. What are the advantages of a serum test compared with a skin test?

  • The Next+ Serum Test is more efficient in terms of time and costs.
  • The Next+ Serum Test is an individualised test for the most relevant allergens.
  • Results are easy to interpret and discuss with the pet parent.
  • There is no need to shave the patient’s fur.
  • Symptomatic medications like corticosteroids and cyclosporin do not need to be discontinued before carrying out the test.

2. Which drugs can be administered without affecting the results of the serum test?
As far as we know, the following medications can be administered without affecting the results1:

  • Corticosteroids (if taken for no longer than 2–3 months)
  • Cyclosporin
  • Antibiotics
  • Anti-fungal drugs
  • Heartworm drugs
  • Anti-flea agents and devices
  • Thyroid medications
  • Heart medications
  • NSAIDs

1Olivery, et al. Evidence-based guidelines for anti-allergic drug withdrawal times before allergen-specific intradermal and IgE serological tests in dogs. Vet Derm 24 (2013) 225–232.

3. Can the Next+ range of products be performed on full blood or plasma instead of serum?
For optimal test completion, serum is preferable. However, samples of plasma or full blood will not negatively affect the result.

4. Is it a problem to use serum tubes other than the ones supplied for collecting serum?
Using a different serum tube is not a problem.

5. What volume of serum do I need to send?
1.5 ml of serum.

6. How long does it take for the results to be ready?
Results are available 2 days after arriving at our laboratory.