Nextmune

CCDs are cross-reactive carbohydrate determinants, which are the carbohydrate chains found in glycoproteins. They are part of the structure of many allergy-causing proteins, especially plant-based allergens like pollen.

During an allergic reaction, IgE is produced against the carbohydrate chains as well as the allergen’s proteins. Studies have confirmed that this occurs in 30% of humans, dogs and cats. The IgE against CCD chains does not seem to be clinically relevant.

Blocking CCDs means that the specificity of the in vitro test is enhanced. Evidence shows that the correlation with intradermal testing is also improved.