Artuvetrin® Therapy

Artuvetrin® Therapy is the only licensed immunotherapy in Europe. It treats the root cause of the allergy and reduces the symptoms.

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Artuvetrin® Therapy is the only licensed immunotherapy in Europe. It treats the root cause of the allergy and reduces the symptoms. Artuvetrin Therapy® is tailored specifically to the individual patient. After determining what the dog, cat or horse is allergic to using our allergy tests, the allergy can be kept under control. Symptoms are greatly reduced and potentially eliminated. This therapy has proven efficacy (75%) and safety, and therefore can be given over long periods.

Key Artuvetrin® Therapy Facts

  • Treats the root cause as well as the symptoms
  • Proven efficacy rate of 75%
  • Proven safety profile
  • The only licensed immunotherapy in Europe
  • The product of choice under European veterinary medicines regulations (Directive 2004/28/EC)
  • Delivery within 8 working days
  • Identical allergens available for allergy testing and therapy
  • One vial provides 10 months of treatment
  • Up to 8 allergens in each vial
  • One vial, one concentration and easy to use

How it works

Artuvetrin® Therapy works by giving repeated doses of allergens that stimulate an immune response and lead to the build-up of immunological tolerance. It is the only treatment that alters the course of an allergic disease while also controlling the symptoms. Compliance with the allergy treatment plan is key to success, and will accelerate recovery and allergy relief.

How to administer?

Artuvetrin® Therapy is administered subcutaneously at increasing doses and increasing intervals to a maximum of 1.0 ml every 4 weeks. The first dose is 0.2 ml, and this is gradually increased to a maximum of 1.0 ml, with longer intervals between each dose. When a dose of 1.0 ml is reached, after 12 weeks, then a fixed dose of 1.0 ml is administered on a monthly basis. In some cases, this treatment schedule is too fast for the patient. In such cases, it is possible to deviate from the standard schedule.

Allergy is a chronic disease so the treatment must continue for the entire lifetime of the patient. A vial of Artuvetrin lasts 10 months, meaning a new vial of immunotherapy is needed every 10 months to continue treatment and to ensure adequate relief of symptoms.


1. Is it possible to deviate from the standard dosing schedule? If so, in what situations?
In some cases deviation from the schedule is recommended. For example, if the patient’s symptoms start or worsen immediately after an injection, then subsequent volumes can be adjusted lowered. Symptomatic medication can also be given, as required, to alleviate symptoms and calm the skin. Another example is when symptoms return 1–2 weeks before the next injection. This means the interval is too long, thus the timing can be adjusted to, for example, 0.8 ml every 3 weeks or 0.5 ml every 2 weeks. Adjusting the interval is only recommended if the patient was already on the maintenance dose (that is, 1 ml every 4 weeks). Our allergy experts will advise on any adjustments or specific cases, contact us here.

2. What is the best time to start the treatment?
Artuvetrin® Therapy can be started at any time, however it is recommended that the skin symptoms are under control before commencing treatment.

3. Do I need to stop symptomatic medication before starting Artuvetrin® Therapy?
No. Symptomatic medication does not need to be stopped. It does not affect the efficacy of the immunotherapy and therefore can be continued alongside it. Such medications can help to keep the skin calm and under control in the initial (increasing dosage) phase of Artuvetrin® Therapy.

4. Can other products be combined with Artuvetrin® Therapy?
A multimodal approach to allergy is very helpful. In conjunction with Artuvetrin® Therapy, other products can help control the symptoms as required. Medicated shampoos, ear cleansers and essential fatty acids all support the skin barrier and help prevent and treat skin infections.

5. When can an improvement in symptoms be expected?
Improvements are usually noticed after 4–6 months. In some cases, improvement can occur after as little as 1 month. If there is no improvement at all after 6 months, please contact us here.

6. Can the treatment be stopped if the symptoms are not present anymore?
No. The treatment is life-long and should not be stopped. Stopping treatment often allows the symptoms to return, and re-starting the treatment from scratch may not be as effective.

7. What if the patient does not respond at all?
If the patient shows no improvement after 12 months, please contact us here. There can be several reasons for this, such as a concomitant food allergy, a reaction to new allergens, or a need to adjust the protocol. We are happy to evaluate each case individually and help you with the relevant follow-up.